synthesis of 7-substituted fluoroquinolone derivatives contain- ing triazolidine dione moiety and in vitro evaluation of their cytotoxic effects
نویسندگان
چکیده
a series of fluoroquinolone derivatives holding triazolidindione moieties have been synthesized and proved to be cytotoxic agents in vitro particularly against cancer cell lines (sknmc, mcf7, a2780-cp, sw48, a549, kb, ht-29, hepg 2 ). the cytotoxic activity was assessed using mtt colorimetric assay. our compounds had less cytotoxicity than doxorubicin in all studied cell lines.
منابع مشابه
evaluation of in vitro antimicrobial and antioxidant activities of 4-substituted-1,2,4-triazolidine-3,5-dione derivatives
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عنوان ژورنال:
journal of reports in pharmaceutical sciencesجلد ۲، شماره ۱، صفحات ۷۵-۸۲
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